Diagnosing and treating Pyrrole Disorder

Susan Hunter Mental Health Leave a Comment

Diagnosing and treating Pyrrole Disorder can help you to solve common health complaints like anxiety, depression, poor stress tolerance, aggression and insomnia.

It’s though that 10 per cent of the population may suffer from Pyrrole Disorder, which is caused by the excretion of large amounts of zinc and B6. Without these minerals at the right level you can suffer side effects like those listed above and other, more subtle ones like hypersensitivity to light, sound and smell.

The good news is that, Pyrrole disorder is relatively simple to diagnose and responds well to treatment.

stress danger signsDiagnosing Pyrrole Disorder

A simple urine test can detect Pyrrole disorder. A special urine collection with a laboratory in your state is required because the Pyrrole proteins excreted in the urine are unstable once outside the body.

It is important that the urine sample is collected in a dimly lit bathroom, the specimen jar is covered in foil to keep light out and the sample must be packed on dry ice when transported to the lab to preserve the specimen. It is important to speak to your health practitioner for more information about collection instructions.

insomnia curesIt is also important to have a blood test done to check your plasma zinc, plasma copper and copper binding protein status. Copper is investigated because it has a relationship with zinc. Ideally we have copper and zinc in our bodies at a 1:1 ratio. However, zinc is often low which leaves high bound or unbound copper levels in the blood, and that can be a problem itself.

The results of these tests will give you a definitive diagnosis.

Treating Pyrrole Disorder

If you test positive for Pyrrole disorder it is important to supplement the missing nutrients under the supervision of a practitioner who is experienced in treating Pyrrole disorder.

As you might have guessed, vitamin B6 and zinc supplementation is crucial. Dosage ranges are high due to the increased level of excretion of the Pyrroles into the urine. When anticipating periods of high stress it is also important to preload bigger doses of those nutrients.

Taking a combination of antioxidants is also important to address the oxidative stress that occurs with Pyroluria.

Gama linoleic acid (GLA) is also used to treat Pyrrole disorder as it is thought that there is an arachadonic acid deficiency present with this disorder. Evening primrose, borage or blackcurrant oil all contain GLA. Doing an essential fatty acid profile with a reputable lab is a good way to work out what types of fatty acids need to be supplemented for each individual.


Treatment may seem simple but should be undertaken under the guidance of a practitioner with extensive experience treating Pyrrole disorder.

Some people will feel terrible when self prescribing zinc and vitamin B6. There can be problems with displacing copper, mobilisation of heavy metals into the circulation and activation of the immune system that can lead to microbial endotoxins being released. All of these need to be taken into consideration before beginning treatment.


Susan Hunter
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